Suspended animation of Drosophila embryos in liquid nitrogen
Biomanufacturing utilizes biological systems, such as living cells, to produce essential products like pharmaceuticals and biomaterials, driving innovation in research, medicine, and environmental sustainability. Complementing this, cryopreservation at cryogenic temperature (i.e., -196 deg C, supercool, literally) stops biological time and enables biobanking for indefinite storage, therefore facilitating on-demand supply of living biological systems (read more here about ATP-Bio). We aim to develop advanced biomanufacturing and cryopreservation techniques to contribute to the vision of a "BioAmazon" to advance biotechnology, healthcare, and sustainability.
Selected Publications:
Zhan, L., Rao, J.S., Sethia, N., Slama, M.Q., Han, Z., Tobolt, D., Etheridge, M., Peterson, Q.P., Dutcher, C.S., Bischof, J.C., Finger, E. Nature Medicine, 2022.
Highlighted by Nature
Reported by Science Daily, ScienMag, EurekAlert!, Mirage News etc.
Rapid joule heating improves vitrification based cryopreservation
Zhan, L., Han, Z., Shao, Q., Etheridge, M.L., Hays, T., and Bischof, J.C. Nature Communications, 2022
Fun to read: surviving suspended animation: a rapid ride across no man's land
Cryopreservation method for Drosophila melanogaster embryos
Zhan, L., Li, M., Hays, T., and Bischof, J. Nature Communications, 2021.
Reported by Science Daily, ScienMag, Phys.org, EurekAlert! etc.
Microfluidic device for label-free cell sorting in whole blood
Micro/nano biomedical devices play a pivotal role in advancing modern biotechnology and healthcare. By operating at micro- and nanoscale dimensions, these devices allows precise manipulation of biological systems, such as cells and biomolecules, unlocking new possibilities in early disease detection, targeted drug delivery, tissue engineering, and personalized medicine. Our goal is to develop accessible and efficient micro/nano devices to improve the diagnosis, monitoring, and treatment of diseases.
Selected Publications:
Label-free microfluidic apheresis of circulating tumor cell clusters
Zhan, L., Edd, J., Mishra, A., and Toner, M. Advanced Science, 2024
Ultrasensitive and highly specific lateral flow assays for point-of-care diagnosis
Liu, Y., Zhan, L., Qin, Z., Sackrison, J., and Bischof, J.C. ACS Nano, 2021
The role of nanoparticle design in determining analytical performance of lateral flow immunoassays
Zhan, L., Guo, S., Song, F., Gong, Y., Xu, F., Boulware, D.R., McAlpine, M.C., Chan, W.C.W., and Bischof, J.C. Nano Letters, 2017